Simple and Reliable Method to Quantify the Hepatitis B Viral Load and Replicative Capacity in Liver Tissue and Blood Leukocytes
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چکیده
منابع مشابه
simple and reliable method to quantify the hepatitis b viral load and replicative capacity in liver tissue and blood leukocytes
results a plasmid construct, including sequences from the hbv genome and from the human gene htert, was generated as an isomolar multi-standard for hbv quantitation and normalization to the cellular contents. the specificity of the real-time assay for the cccdna was assessed using dane particles isolated on a density gradient. a comparison of liver tissue from 6 untreated and 6 treated patients...
متن کاملSimple and Reliable Method to Quantify the Hepatitis B Viral Load and Replicative Capacity in Liver Tissue and Blood Leukocytes
BACKGROUND A functional cure of chronic hepatitis B (CHB) is feasible, but a clear view of the intrahepatic viral dynamics in each patient is needed. Intrahepatic covalently closed circular DNA (cccDNA) is the stable form of the viral genome in infected cells, and represents the ideal marker of parenchymal colonization. Its relationships with easily accessible peripheral parameters need to be e...
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Background: Serial measurement of hepatitis B virus (HBV) DNA levels in the liver and its relation with liver damage and serum HBV DNA levels are guide to begin and/or end a treatment course. This study evaluated the relationship between liver hepatitis B DNA viral load with liver histology in patients with chronic hepatitis B (HBV). Methods: Thirty patients with chronic anti-Hbe positive ...
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Introduction: Hepatitis B virus (HBV) infection is a global public health problem. Serum HBV DNA measurement is a non-invasive test that predicts the liver disease progression. The aim of this study was to determine the HBV DNA level and look for a relation between the HBV DNA level and liver histology. Methods: This was a cross sectional study on chronic...
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ژورنال
عنوان ژورنال: Hepatitis Monthly
سال: 2016
ISSN: 1735-143X,1735-3408
DOI: 10.5812/hepatmon.28751